|Sample Requirement||Turnaround Time|
|Serum||Same working day|
Troponin is a protein complex composed of three subunits: TnI (troponin inhibitory component), which prevents muscle contractions in the absence of calcium; TnT (tropomyosin-binding component), which connects the troponin complex with tropomyosin; and TnC (calcium binding component), which binds calcium.
The cardiac muscle-specific isoform cTnI exhibits approximately 60% homology with the skeletal isoforms (sTnI) but has a unique 31 amino acid extension of the N-terminus.
After acute myocardial infarction (AMI), elevated cTnI levels appear in the circulation within 3-6 hours.
Serum levels peak within 14-20 hours and return to normal after 5-7 days. In horses myocardial infarction is rare, but increases do occur in some other forms of cardiac disease that cause myocyte damage.
Raised cTnI levels are an indication for cardiac ultrasound examinations and ambulatory EcG monitoring, and are useful monitoring response to treatment/monitoring. Normal cTnI does not exclude all forms of cardiac disease in horses.
Cardiac troponin (cTnI) levels are measured in serum samples (lower results may be found in plasma samples).
|Adult Non-Thoroughbred Horses||0.05-0.2|
|Neonatal Thoroughbred Foals (24-48hrs old)||0.18-0.79|
|Two-Year-Old Thoroughbred Horses in Training||0.10-0.36|
|Three-Year-Old Thoroughbred Horses in Training||0.10-0.36|
|Adult Thoroughbred Horses at Stud||0.05-0.2|