|Sample Requirement||Turnaround Time|
|Serum||Same working day|
GGT is found in cell membranes of hepatocytes and biliary epithelial cells, but the enzyme is also found in the pancreas and kidney (proximal convoluted tubule).
Elevations in serum levels are seen in the presence of acute hepatitis, chronic liver cirrhosis and in very rare cases of pancreatitis. Nephropathy does not usually result in significantly raised serum GGT levels so high levels measured in the horse are usually a sign of biliary or cholestatic disease. Chronic pyrrolizidine alkaloid (ragwort (Senecio jacobea)) toxicity causes bile duct hyperplasia and biliary stasis and therefore typically results in raised serum GGT and SAP levels.
Idiopathic GGT elevations are sometimes seen in horses in training that appear otherwise healthy, but perform poorly.
Urine GGT:creatinine ratios are elevated (>25%) in renal tubular pathology.
|Adult Non-Thoroughbred Horses||1-40|
|Neonatal Thoroughbred Foals (24-48hrs old)||10-32|
|Older Thoroughbred Foals (approx. 3 weeks old)||13-30|
|Yearling Thoroughbred Horses||10-30|
|Two-Year-Old Thoroughbred Horses in Training||12-40|
|Three-Year-Old Thoroughbred Horses in Training||13-47|
|Adult Thoroughbred Horses at Stud||14-28|